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Title 

High-performance dendritic contrast agents for X-ray computed tomography imaging using potent tetraiodobenzene derivatives

Authors 

Suyeon YouHye-youn JungChaewoon LeeYun Hui ChoeJu Young HeoGil Tae GangSang-Kyung ByunWon Kon KimChul Ho LeeD E KimY I KimYoonkyung Kim

Publisher 

Elsevier

Issue Date 

2016

Citation 

Journal of Controlled Release, vol. 226, no. 0, pp. 258-267

Abstract 

The use of computed tomography (CT) for vascular imaging is critical in medical emergencies requiring urgent diagnostic decisions, such as cerebral ischemia and many cardiovascular diseases. Small-molecule iodinated contrast media are often injected intravenously as radiopaque agents during CT imaging to achieve high contrast enhancement of vascular systems. The rapid excretion rate of these agents is overcome by injecting a significantly high dose of iodine, which can have serious side effects. Here we report a simple method to prepare blood-pool contrast agents for CT based on dendrimers for the first time using tetraiodobenzene derivatives as potent radiopaque moieties. Excellent in vivo safety has been demonstrated for these small (13-22nm) unimolecular water-soluble dendritic contrast agents, which exhibit high contrast enhancement in the blood-pool and effectively extend their blood half-lives. Our method is applicable to virtually any scaffold with suitable surface groups and may fulfill the current need for safer, next-generation iodinated CT contrast agents.

ISSN 

0168-3659

Link 

http://dx.doi.org/10.1016/j.jconrel.2016.01.036

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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