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Title 

GPR171 expression enhances proliferation and metastasis of lung cancer cells

 

GPR171 단백질의 폐암세포 증식 및 전이 조절 기전

Authors 

So Hee DhoKwang-Pyo LeeD JeongC J KimKyung-Sook ChungJi Young KimBum Chan ParkSung Sup ParkSeon-Young KimKi Sun Kwon

Publisher 

Impact Journals

Issue Date 

2016

Citation 

Oncotarget, vol. 7, no. 7, pp. 7856-7865

Keywords 

EGFRGPCRGPR171Lung cancer

Abstract 

G protein-coupled receptors (GPCRs) are among the most significant therapeutic targets and some of them promote the growth and metastasis of cancer. Here, we show that an increase in the levels of GPR171 is crucial for lung cancer tumor progression in vitro and in vivo. Immunostaining of clinical samples indicated that GPR171 was overexpressed in 46.8% of lung carcinoma tissues. Depletion of GPR171 with an anti-GPR171 antibody decreased proliferation of lung carcinoma cells and attenuated tumor progression in a mouse xenograft model. Knockdown of GPR171 also inhibited migration and invasion of the lung cancer cell lines. Notably, inhibition of GPR171 synergistically enhanced the tumoricidal activity of an epidermal growth factor receptor (EGFR) inhibitor in lung cancer cells. These results indicate that GPR171 blockade is a promising antineoplastic strategy and provide a preclinical rationale for combined inhibition of GPR171 and EGFR.

ISSN 

1949-2553

Link 

http://dx.doi.org/10.18632/oncotarget.6856

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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