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Title 

Nano-Fenton reactors as a new class of oxidative stress amplifying anticancer therapeutic agents

 

ROS에 의한 항암 효과

Authors 

B KwonE HanW YangW ChoW YooJ HwangByoung-Mog KwonD Lee

Publisher 

American Chemical Society

Issue Date 

2016

Citation 

ACS Applied Materials and Interfaces, vol. 8, no. 9, pp. 5887-5897

Keywords 

cancerFenton reactionhydroxyl radicaloxidative stresspolymeric micelles

Abstract 

Cancer cells, compared to normal cells, are under oxidative stress associated with an elevated level of reactive oxygen species (ROS) and are more vulnerable to oxidative stress induced by ROS generating agents. Thus, manipulation of the ROS level provides a logical approach to kill cancer cells preferentially, without significant toxicity to normal cells, and great efforts have been dedicated to the development of strategies to induce cytotoxic oxidative stress for cancer treatment. Fenton reaction is an important biological reaction in which irons convert hydrogen peroxide (H2O2) to highly toxic hydroxyl radicals that escalate ROS stress. Here, we report Fenton reaction-performing polymer (PolyCAFe) micelles as a new class of ROS-manipulating anticancer therapeutic agents. Amphiphilic PolyCAFe incorporates H2O2-generating benzoyloxycinnamaldehyde and iron-containing compounds in its backbone and self-assembles to form micelles that serve as Nano-Fenton reactors to generate cytotoxic hydroxyl radicals, killing cancer cells preferentially. When intravenously injected, PolyCAFe micelles could accumulate in tumors preferentially to remarkably suppress tumor growth, without toxicity to normal tissues. This study demonstrates the tremendous translatable potential of Nano-Fenton reactors as a new class of anticancer drugs.

ISSN 

1944-8244

Link 

http://dx.doi.org/10.1021/acsami.5b12523

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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