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Title 

Shiga toxins as multi-functional proteins: induction of host cellular stress responses, role in pathogenesis and therapeutic applications

 

감염성 시가독소의 다중기능성: 숙주세포 반응유도, 병리기전 및 치료에의 적용

Authors 

Moo-Seung LeeS KooDae Gwin JeongV L Tesh

Publisher 

MDPI

Issue Date 

2016

Citation 

Toxins, vol. 8, no. 3, pp. 77-77

Abstract 

Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae serotype 1 and select serotypes of Escherichia coli are primary virulence factors in the pathogenesis of hemorrhagic colitis progressing to potentially fatal systemic complications, such as hemolytic uremic syndrome and central nervous system abnormalities. Current therapeutic options to treat patients infected with toxin-producing bacteria are limited. The structures of Stxs, toxin-receptor binding, intracellular transport and the mode of action of the toxins have been well defined. However, in the last decade, numerous studies have demonstrated that in addition to being potent protein synthesis inhibitors, Stxs are also multifunctional proteins capable of activating multiple cell stress signaling pathways, which may result in apoptosis, autophagy or activation of the innate immune response. Here, we briefly present the current understanding of Stx-activated signaling pathways and provide a concise review of therapeutic applications to target tumors by engineering the toxins.

ISSN 

2072-6651

Link 

http://dx.doi.org/10.3390/toxins8030077

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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