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Title 

Neurorestorative role of stem cells in Alzheimer's disease: astrocyte involvement

Authors 

S S ChoiSang-Rae LeeH J Lee

Publisher 

Bentham Science Publishers

Issue Date 

2016

Citation 

Current Alzheimer Research, vol. 13, no. 4, pp. 419-427

Keywords 

Alzheimer’s diseaseAstrocyteNeurogenesisRegenerative medicineStem cell based gene therapyTransplantation

Abstract 

Neurogenesis is maintained in both neonatal and adult brain, although it is dramatically reduced in aged neurogenic brain region such as the subgranular layer and subventricular zone of the dentate gyrus (DG). Astrocytes play important roles for survival and maintenance of neurons as well as maintenance of neurogenic niche in quiescent state. Aβ can induce astrocyte activation which give rise to produce reactive oxygen species (ROS) and cytotoxic cytokines and chemokines, and subsequently induce neuronal death. Unfortunately, the current therapeutic medicines have been limited to reduce the symptoms and delay the pathogenesis of Alzheimer’s disease (AD), but not to cure it. Stem cells enhance neurogenesis and Aβ clearing as well as improved cognitive impairment. Neurotrophins and growth factors which are produced from both stem cells and astrocytes also have neuroprotective effects via neurogenesis. Secreted factors from both astrocytes and neural stem cells also are influenced in neurogenesis and neuron survival in neurodegenerative diseases. Transplanted stem cells overexpressing neurogenic factors may be an effective and therapeutic tool to enhance neurogenesis for AD.

ISSN 

1567-2050

Link 

http://dx.doi.org/10.2174/156720501304160314162812

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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