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Title 

New cyclic lipopeptides of the iturin class produced by saltern-derived Bacillus sp. KCB14S006

 

염전유래 Bacillus sp. KCB14S006로부터 분리한 신규 cyclic lipopeptides

Authors 

Sangkeun SonSung-Kyun KoMina JangJong Won KimGil Soo KimJae Kyoung LeeEun Soo JeonY FutamuraIn Ja RyooJung-Sook LeeH OhYoung-Soo HongBo Yeon KimS TakahashiH OsadaJae-Hyuk JangJong Seog Ahn

Publisher 

MDPI

Issue Date 

2016

Citation 

Marine Drugs, vol. 14, no. 4, pp. 72-72

Keywords 

AntifungalCytotoxicIndoleamine-2,3-dioxygenaseIturinsSaltern-derived bacteria

Abstract 

Salterns, one of the most extreme natural hypersaline environments, are a rich source of halophilic and halotolerant microorganisms, but they remain largely underexplored ecological niches in the discovery of bioactive secondary metabolites. In continued efforts to investigate the metabolic potential of microbial populations from chemically underexplored sites, three new lipopeptides named iturin F1, iturin F2 and iturin A9 (1-3), along with iturin A8 (4), were isolated from Bacillus sp. KCB14S006 derived from a saltern. The structures of the isolated compounds were established by 1D-, 2D-NMR and HR-ESIMS, and their absolute configurations were determined by applying advanced Marfey's method and CD spectroscopy. All isolates exhibited significant antifungal activities against various pathogenic fungi and moderate cytotoxic activities toward HeLa and srcts-NRK cell lines. Moreover, in an in vitro enzymatic assay, compound 4 showed a significant inhibitory activity against indoleamine 2,3-dioxygenase.

ISSN 

1660-3397

Link 

http://dx.doi.org/10.3390/md14040072

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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