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Title 

Genkwadaphnin promotes leukocyte migration by increasing CD44 expression via PKD1/NF-κB signaling pathway

Authors 

Nina YooHa-Reum LeeJang-Mi SonHo-Bum KangHee Gu LeeSuk Ran YoonS Y YoonJae Wha Kim

Publisher 

Elsevier

Issue Date 

2016

Citation 

Immunology Letters, vol. 173, no. 0, pp. 69-76

Keywords 

CD44GenkwadaphninLeukocyteMigrationNF-κBPKD1

Abstract 

Genkwadaphnin (GD), an extract from the flower buds of Daphne genkwa Siebold & Zucc. (Thymelaeaceae) has been reported a significant anti-leukemic activity. However, its functional mechanism has not been defined well. To study the biological mechanism of GD function, we have investigated whether GD affects CD44 expression, which has a role in the regulation of immune cell motilities, and identified the related signaling pathways. GD treatment induced the increase of CD44 expression in a time- and concentration-dependent manner, which was specific for immune cells. GD activated PKD1/NF-κB signaling to induce CD44 expression, and resulted in the increased migration of K562 cells. In invasion assay, cell migratory ability was induced by GD and the transfection with CD44-specific short hairpin RNA resulted in reduction of its cell migration. GD treated human peripheral blood mononuclear cell (PBMC) were also shown the increased CD44 expression and migration. These data suggest that the induction of CD44 expression by GD treatment promotes immune cell transmigration resulting in the enhanced innate immunity.

ISSN 

0165-2478

Link 

http://dx.doi.org/10.1016/j.imlet.2016.03.006

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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