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Title 

Protective efficacy of Streptococcus iniae derived enolase against Streptococcal infection in a zebrafish model

Authors 

J D MembrebeNam Kyung YoonMinhee HongJeongsoo LeeHong-Weon LeeK ParkS H SeoI YoonS YooY C KimJungoh Ahn

Publisher 

Elsevier

Issue Date 

2016

Citation 

Veterinary Immunology and Immunopathology, vol. 170, no. 0, pp. 25-29

Keywords 

Streptococcus iniaeStreptococcus parauberisSubunit vaccineZebrafishα-Enolase

Abstract 

Enolase (ENO) is one of the surface-exposed proteins of Streptococcus iniae, which previously had been identified as a plasminogen-binding protein. In this study, ENO was evaluated to induce cross-protective immunity against S. iniae and Streptococcus parauberis which are major pathogens causing streptococcosis in fish. Immunoblot analysis shows that S. iniae recombinant ENO (rENO) produced in Escherichia coli was cross-reactive with antisera against S. iniae, and S. parauberis serotype I and II. In the challenge experiment of streptococcal infection after vaccination in zebrafish, rENO elicited a similar protection with a whole cell bacterin against S. iniae and S. parauberis, which suggests its feasibility as an efficient vaccine against streptococcosis.

ISSN 

0165-2427

Link 

http://dx.doi.org/10.1016/j.vetimm.2016.01.004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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