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Title 

Extract of Ettlia sp. YC001 exerts photoprotective effects against UVB irradiation in normal human dermal fibroblasts

Authors 

J J LeeS AnK B KimJina HeoDae Hyun ChoHee-Mock OhHee-Sik KimS Bae

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2016

Citation 

Journal of Microbiology and Biotechnology, vol. 26, no. 4, pp. 775-783

Keywords 

Dermal fibroblastsEttlia sp. YC001PhotoagingPhotoprotectionSkinUltraviolet B

Abstract 

The identification of novel reagents that exert a biological ultraviolet (UV)-protective effect in skin cells represents an important strategy for preventing UV-induced skin aging. To this end, we investigated the potential protective effects of Ettlia sp. YC001 extracts against UV-induced cellular damage in normal human dermal fibroblasts (NHDFs). We generated four different extracts from Ettlia sp. YC001, and found that they exhibit low cytotoxicity in NHDFs. The ethyl acetate extract of Ettlia sp. YC001 markedly decreased UVB-induced cytotoxicity. Additionally, the ethyl acetate extract significantly inhibited the production of hydrogen peroxide-induced reactive oxygen species. Moreover, it inhibited UVB-induced thymine dimers, as confirmed by luciferase assay and thymine dimer dot-blot assay. Thus, the study findings suggest Ettlia sp. YC001 extract as a novel photoprotective reagent on UVB-induced cell dysfunctions in NHDFs.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1509.09067

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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