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Title 

Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease

Authors 

Mi Young SonMi Ok LeeHyejin JeonBinna SeolJ H KimJ S ChangYee Sook Cho

Publisher 

Korean Society of Medical Biochemistry

Issue Date 

2016

Citation 

Experimental and Molecular Medicine, vol. 48, no. 0, pp. e232-e232

Abstract 

Plasmacytoid dendritic cells (pDCs) are unique bone-marrow-derived cells that produce large amounts of type I interferon in response to microbial stimulation. Furthermore, pDCs also promote T cell tolerance in sterile-inflammation conditions. However, the immunomodulatory role of aortic pDCs in atherosclerosis has been poorly understood. Here, we identified functional mouse and human pDCs in the aortic intima and showed that selective, inducible pDC depletion in mice exacerbates atherosclerosis. Aortic pDCs expressed CCR9 and indoleamine 2,3-dioxygenase 1 (IDO-1), an enzyme involved in driving the generation of regulatory T cells (Tregs). As a consequence, loss of pDCs resulted in decreased numbers of Tregs and reduced IL-10 levels in the aorta. Moreover, antigen presentation by pDCs expanded antigen-specific Tregs in the atherosclerotic aorta. Notably, Tregs ablation affected pDC homeostasis in diseased aorta. Accordingly, pDCs in human atherosclerotic aortas colocalized with Tregs. Collectively, we identified a mechanism of atheroprotection mediated by tolerogenic aortic pDCs.

ISSN 

1226-3613

Link 

http://dx.doi.org/10.1016/j.cmet.2016.04.010

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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