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Title 

Ingenane-type diterpene compounds from Euphorbia kansui modulate IFN-? production through NF-?B activation

Authors 

Sehyun OhHyun Woo OhHa-Reum LeeS Y YoonSei-Ryang OhYoung-Eun GoNina YooJinseon JeongJae Wha Kim

Publisher 

Society of Chemical Industry

Issue Date 

2016

Citation 

Journal of the Science of Food and Agriculture, vol. 96, no. 8, pp. 2635-2640

Keywords 

Euphorbia kansuiIFN-gammaNF-κBNK cells

Abstract 

BACKGROUND: Euphorbia kansui, a traditional medical herb, has been shown to have anti-tumour and anti-viral activities. Previously, we have reported that E. kansui increases interferon-gamma (IFN-γ) production in natural killer (NK) cells. However, it is not clear how E. kansui regulates IFN-γ secretion by NK cells. RESULTS: In this study, E. kansui was separated into six individual compounds from the same chloroform fraction so that the activity of each compound could be compared. E. kansui compounds induced IFN-γ secretion through the phosphorylation of protein kinase D and IκB kinase pathways. Furthermore, E. kansui compounds activated the translocation of p65, a sub-unit of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), to the nucleus and induced NF-κB at the transcriptional level. CONCLUSION: These findings suggest that E. kansui enhances IFN-γ secretion through the NF-κB pathway in NK cells.

ISSN 

0022-5142

Link 

http://dx.doi.org/10.1002/jsfa.7380

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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