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Title 

Phenylacylphenol derivatives with anti-melanogenic activity from Stewartia pseudocamellia

Authors 

Zuh Kyung SeongH S KimYu Mi WonJae Lim KimHyuk-Hwan SongDoo-Young KimSei-Ryang OhH W ChoJ H ChoHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2016

Citation 

Archives of Pharmacal Research, vol. 39, no. 5, pp. 636-645

Keywords 

Anti-melanogenic activityMelanogenesisMurine B16 melanoma cellsPhenylacylphenolStewartia pseudocamellica

Abstract 

Three new phenylacylphenol derivatives, stewartianol (1), deoxystewartianol-4′-O-arabinoglucoside (2), and stewartianol-3-O-glucoside (3), along with nine known compounds, methylesculin (4), fraxoside (5), fraxetin (6), scopletin (7), (+)-dihydromyricetin (8), (+)-taxifolin-7-O-β-d-glucose (9), (+)-taxifolin (10), (+)-dihydrokaempferol-7-O-β-d-glucose (11), and 3-acetyl-ursolic acid (12), were isolated from the twigs of Stewartia pseudocamellia; commonly used as folk medicine in Korea. The structures of the isolated compounds were identified using spectroscopic analysis, including 1D, 2D NMR, MS and compared with published data. The compounds were tested for their anti-melanogenic activity in cultured murine B16 melanoma cells. Stewartianol (1) and stewartianol-3-O-glucoside (3) showed an inhibitory effect significantly on melanogenesis in a concentration-dependent manner.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-016-0717-9

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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