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Title 

Aqueous extraction of citrus unshiu peel induces proangiogenic effects through the FAK and ERK1/2 signaling pathway in human umbilical vein endothelial cells

Authors 

J LeeD S YangS I HanJ H YunI W KimSeung Jun KimJ H Kim

Publisher 

Mary Ann Liebert

Issue Date 

2016

Citation 

Journal of Medicinal Food, vol. 19, no. 6, pp. 569-577

Keywords 

angiogenesisCitrus unshiu peelERK1/2FAKhesperidin

Abstract 

Citrus unshiu peel has been used empirically as a traditional medicine to improve bronchial asthma and blood circulation in northeast Asian nations, including Korea, Japan, and China. In this study, we report the proangiogenic effects of the aqueous extract of Citrus unshiu peel (AECUP). In human umbilical vein endothelial cells, AECUP significantly induced cellular migration and capillary tube formation. We also demonstrated that AECUP markedly increased the phosphorylation of FAK and ERK1/2 through the integrin signaling pathway. Additionally, we identified that narirutin and hesperidin were major constituents of AECUP and both showed proangiogenic effects, but at different levels. Collectively, these results suggest that the AECUP may have potential as a therapeutic agent for improving angiogenic functions with reduced harmful side effects.

ISSN 

1096-620X

Link 

http://dx.doi.org/10.1089/jmf.2015.3584

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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