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Title 

Anti-obesity effects of spiramycin in vitro and in vivo

Authors 

Mun-Ock KimHyung Won RyuJi Hee ChoiTae Hyun SonSei-Ryang OhHyun Sun LeeHeung Joo YukSungchan ChoJong Soon KangChang Woo LeeJinhyuk LeeC K LeeS T HongSu Ui Lee

Publisher 

Public Library of Science

Issue Date 

2016

Citation 

Plos One, vol. 11, no. 7, pp. e0158632-e0158632

Abstract 

The effects of spiramycin on adipogenesis and high fat diet (HFD)-induced obesity were investigated. Potential mechanisms contributing to these effects were elucidated. The inhibitory effect of spiramycin on adipocyte differentiation was assessed using 3T3-L1 preadipocyte cells, in which several parameters involved in AMPK signal pathways and lipid metabolism were examined. To further investigate the pharmacological effects of spiramycin in vivo, we examined several obesity-related parameters in HFD-induced obese mice. Spiramycin significantly inhibited preadipocyte differentiation by attenuating intracellular lipid accumulation. Spiramycin also reduced the expression of adipogenic master regulators (PPARγ, C/EBPα, and SREBP1c) and their downstream target genes (FAS, aP2, and GLUT4) in 3T3-L1 cells. In addition, AMPK phosphorylation was increased by spiramycin treatment in 3T3-L1 cells during early differentiation. Notably, HFD-induced obese mice administered spiramycin showed substantial decreases in body weight gain, serum leptin levels, adipose tissue mass, and hepatic lipid accumulation. Moreover, the decreased levels of GPT and GOT in the serum indicated that spiramycin attenuated hepatic injury caused by HFD. Taken together, these results demonstrate for the first time that spiramycin effectively attenuates HFD-induced obesity and hepatic steatosis by inhibiting adipogenesis.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0158632

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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