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Title 

Asiatic acid inhibits pulmonary inflammation induced by cigarette smoke

Authors 

Jae Won LeeHyun Ah ParkOk-Kyoung KwonYin-Gi JangJu Yeong KimBo Kyung ChoiH J LeeSang Woo LeeJin Hyub PaikSei-Ryang OhKyung Seop AhnHyun-Jun Lee

Publisher 

Elsevier

Issue Date 

2016

Citation 

International Immunopharmacology, vol. 39, no. 0, pp. 208-217

Keywords 

Asiatic acidCigarette smokeHO-1MAPKsNF-kBPulmonary inflammation

Abstract 

Asiatic acid (AA) is one of the major components of Titrated extract of Centella asiatica (TECA), which has been reported to possess antioxidant and anti-inflammatory activities. The purpose of this study was to investigate the protective effect of AA on pulmonary inflammation induced by cigarette smoke (CS). AA significantly attenuated the infiltration of inflammatory cells in bronchoalveolar lavage fluid (BALF) of CS exposure mice. AA also decreased ROS production and NE activity, and inhibited the release of proinflammatory cytokines in BALF. AA reduced the recruitment of inflammatory cells and MCP-1 expression in lung tissue of CS exposure mice. AA also attenuated mucus overproduction, and decreased the activation of MAPKs and NF-kB in lung tissue. Furthermore, AA increased HO-1 expression and inhibited the reduced expression of SOD3 in lung tissue. These findings indicate that AA effectively inhibits pulmonary inflammatory response, which is an important process in the development of chronic obstructive pulmonary disease (COPD) via suppression of inflammatory mediators and induction of HO-1. Therefore, we suggest that AA has the potential to treat inflammatory disease such as COPD.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2016.07.010

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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