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Title 

Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation

 

아출로부터 분리된 세스퀴테르페노이드 화합물의 TLR-4 저해활성

Authors 

Hyun Jae JangJin Han KimHyun-Mee OhMin Suk KimJin Ha JoKyungsook JungSoyoung LeeY H KimWoo Song LeeSeung Woong LeeMun Chual Rho

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2016

Citation 

Chemical & Pharmaceutical Bulletin, vol. 64, no. 7, pp. 1062-1066

Keywords 

Curcuma phaeocaulisLipopolysaccharide (LPS)SesquiterpenoidToll-like receptor 4 (TLR4)Zingiberaceae

Abstract 

Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.c16-00086

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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