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Title 

Magnetic nanovector enabling miRNA-34a delivery for CD44 suppression with concurrent MR imaging

Authors 

H LeeH O KimH Y SonS B LeeE JangB KangS HaamEun Kyung LimY M Huh

Publisher 

American Scientific Publishers

Issue Date 

2016

Citation 

Journal of Nanoscience and Nanotechnology, vol. 16, no. 12, pp. 12939-12946

Keywords 

CD44Gene deliveryMagnetic nanovectorMagnetic resonance imagingmiRNASurface modification

Abstract 

We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.

ISSN 

1533-4880

Link 

http://dx.doi.org/10.1166/jnn.2016.13797

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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