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Title 

Facile and sensitive detection of influenza viruses using SERS antibody probes

Authors 

Jeong MoonSo Yeon YiAhreum HwangGayoung EomJieun SimJinyoung JeongEun Kyung LimBong Hyun ChungB KimJuyeon JungTaejoon Kang

Publisher 

Royal Society of Chemistry

Issue Date 

2016

Citation 

RSC Advances, vol. 6, no. 87, pp. 84415-84419

Abstract 

It is highly important to identify influenza viruses rapidly and accurately for the prevention of future pandemic outbreaks. We developed an easy and sensitive influenza virus detection method using surface-enhanced Raman scattering (SERS) antibody probes. The SERS antibody probes can be prepared easily by mixing Au nanoparticles, gold binding peptide-protein G, and antibodies without complicated chemical or biological reactions. They also retain the optimal conformation for the antibody's interaction with Influenza A/CA/07/2009 (pH1N1), allowing us to detect pH1N1 sensitively and selectively. This method provides a detection limit of 4.1 × 103 TCID per mL and is highly selective for pH1N1. We anticipate that this method can be useful in a wide range of immunoassays.

ISSN 

2046-2069

Link 

http://dx.doi.org/10.1039/c6ra13966c

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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