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Title 

Inhibitory effect of imiquimod-induced psoriasis-like skin inflammation in mice by histamine H4 receptor agonist 4-methylhistamine

Authors 

C H KimJ M LeeJ K YooJi-Su KimSun-Uk KimKyu Tae ChangY K Choo

Publisher 

Wiley

Issue Date 

2016

Citation 

Scandinavian Journal of Immunology, vol. 83, no. 6, pp. 409-417

Abstract 

Psoriasis is a chronic inflammatory immune-mediated autoimmune skin disorder. The histamine H4 receptor (H4R) agonist 4-methylhistamine (4-MH) plays an important role in immunomodulation of inflammatory responses associated with allergic inflammatory diseases. In this study, we investigated the effects of H4R agonist 4-MH on the development of imiquimod (IMQ)-induced psoriasis-like skin inflammation in mice and explored the immunoregulatory mechanism involved. The total clinical severity scores were significantly ameliorated by treatment with 4-MH (20?mg/kg) and 4-MH (40?mg/kg). Histological analysis of the skin revealed that 4-MH (20?mg/kg) and 4-MH (40?mg/kg) significantly attenuated the psoriatic phenotypes, including epidermal hyperplasis, hyperkeratosis and lymphocytes infiltration. Treatment with 4-MH (20?mg/kg) and 4-MH (40?mg/kg) led to reductions in the levels of Th1 cytokines (TNF-α, IFN-α, and IL-27) in the serum and dorsal skin, whereas Th17 cytokines levels (IL-17A and IL-23) did not change in response to treatment with 4-MH (20?mg/kg) and 4-MH (40?mg/kg). Furthermore, the number of CD4+CD25+FoxP3+ regulatory T (Treg) cells was significantly increased by treatment with 4-MH (40?mg/kg). Taken together, these results imply that H4R agonist 4-MH might be an effective immunomodulatory approach for treatment of patients with psoriasis and the effects may be related to inhibited epidermal alteration, selectively reduced Th1 pro-inflammatory cytokines, and recruited CD4+CD25+FoxP3+ Treg cells.

ISSN 

0300-9475

Link 

http://dx.doi.org/10.1111/sji.12420

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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