상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

The last ten years of advancements in plant-derived recombinant vaccines against hepatitis B

 

식물-유래 간염 재조합 백신의 지난 10여년간 발전

Authors 

Y H JoungS H ParkKi Beom MoonJae Heung JeonHye Sun ChoHyun Soon Kim

Publisher 

MDPI AG

Issue Date 

2016

Citation 

International Journal of Molecular Sciences, vol. 17, no. 0, pp. 1715-1715

Keywords 

AntigenHepatitis B virusMolecular farmingPlant edible vaccineRecombinant proteinVirus-like particles

Abstract 

Disease prevention through vaccination is considered to be the greatest contribution to public health over the past century. Every year more than 100 million children are vaccinated with the standard World Health Organization (WHO)-recommended vaccines including hepatitis B (HepB). HepB is the most serious type of liver infection caused by the hepatitis B virus (HBV), however, it can be prevented by currently available recombinant vaccine, which has an excellent record of safety and effectiveness. To date, recombinant vaccines are produced in many systems of bacteria, yeast, insect, and mammalian and plant cells. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins. Research groups worldwide have attempted to develop more efficacious plant-derived vaccines for over 30 diseases, most frequently HepB and influenza. More inspiring, approximately 12 plant-made antigens have already been tested in clinical trials, with successful outcomes. In this study, the latest information from the last 10 years on plant-derived antigens, especially hepatitis B surface antigen, approaches are reviewed and breakthroughs regarding the weak points are also discussed.

ISSN 

1422-0067

Link 

http://dx.doi.org/10.3390/ijms17101715

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


Files in This Item: SizeFormat
14325.pdf327KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)