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Title 

Beneficial effects of pterocarpan-high soybean leaf extract on metabolic syndrome in overweight and obese Korean subjects: randomized controlled trial

Authors 

R RyuTae Sook JeongY J KimJ Y ChoiS J ChoE Y KwonU J JungHyeon Seon JiD H ShinM S Choi

Publisher 

MDPI

Issue Date 

2016

Citation 

Nutrients, vol. 8, no. 0, pp. 734-734

Keywords 

InflammationMetabolic syndromeMRNA sequencingPBMCsSoybean leaf

Abstract 

Pterocarpans are known to have antifungal and anti-inflammatory properties. However, little is known about the changes in transcriptional profiles in response to a pterocarpan-high soybean leaf extract (PT). Therefore, this study investigated the effects of PT on blood glucose and lipid levels, as well as on the inflammation-related gene expression based on a peripheral blood mononuclear cells (PBMCs) mRNA sequencing analysis in Korean overweight and obese subjects with mild metabolic syndrome. The participants were randomly assigned to two groups and were administered either placebo (starch, 3 g/day) or PT (2 g/day) for 12 weeks. The PT intervention did not change body weight, body fat percentage and body mass index (BMI). However, PT significantly decreased the glycosylated hemoglobin (HbA1c), plasma glucose, free fatty acid, total cholesterol, and non-HDL cholesterol levels after 12 weeks. Furthermore, PT supplementation significantly lowered the homeostatic index of insulin resistance, as well as the plasma levels of inflammatory markers. Finally, the mRNA sequencing analysis revealed that PT downregulated genes related to immune responses. PT supplementation is beneficial for the improvement of metabolic syndrome by altering the fasting blood and plasma glucose, HbA1c, plasma lipid levels and inflammation-related gene expression in PBMCs.

ISSN 

2072-6643

Link 

http://dx.doi.org/10.3390/nu8110734

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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