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Title 

Human soluble delta-like 1 homolog exerts antitumor effects in vitro and in vivo

Authors 

Donghee LeeSun Ha YoonHyun Ju LeeK W JoBum Chan ParkI S KimY ChoiJ C LimYoung Woo Park

Publisher 

Elsevier

Issue Date 

2016

Citation 

Biochemical and Biophysical Research Communications, vol. 475, no. 2, pp. 209-215

Keywords 

CancerDelta-like 1 homologExtracellular soluble DLK1Membrane proteinProteolysis

Abstract 

Proteolysis of delta-like 1 homolog (DLK1), a cell-surface transmembrane protein, produces an active soluble form of DLK1 (sDLK1). Both membrane-bound DLK1 and sDLK1 modulate multiple developmental processes including adipogenesis, osteogenesis, chondrogenesis and myogenesis. However, cancer-related functions of DLK1 have not yet been established. We thus evaluated the roles of extracellular sDLK1, comprising six EGF-like domains and juxtamembrane regions, in human pancreatic cancer MIA PaCa-2 cells in vitro and in vivo. We observed that sDLK1 exerted antitumor effects not only in cancer cell migration and anchorage-independent cell growth but also in in vivo tumor growth

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2016.05.076

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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