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Title 

The constituent, anti-inflammation, and human neutrophil elastase inhibitory activity of Gnaphalium affine

 

떡쑥의 성분, 항염증 및 인간호중구 엘라스테이즈 억제활성

Authors 

Hyung Won RyuKi Ohk KimHeung Joo YukOk-Kyoung KwonJung Hee KimDoo-Young KimM K NaKyung Seop AhnSei-Ryang Oh

Publisher 

Journal of Functional Foods

Issue Date 

2016

Citation 

Journal of Functional Foods, vol. 27, no. 0, pp. 674-684

Keywords 

Flavonoid-caffeoyl-glucosideGnaphalium affineHuman neutrophil elastaseNOPro-inflammatory cytokine

Abstract 

Gnaphalium affine has long been used as a vegetable and as a traditional medicine to treat various diseases in East Asia. In this work, the human neutrophil elastase inhibitory activity and anti-inflammatory effects of the lead phytochemicals isolated from G. affine and their effects on respiratory disease agents were evaluated in vitro. Through activity-guided fractionation, eight compounds (1?8) with different scaffolds were isolated from the EtOAc fraction of G. affine extract (GAE). The GAE inhibited LPS-induced NO production with different potencies. The highest potency for the inhibition of NO, iNOS, and pro-inflammatory cytokine production was found in isolated compounds (1?8). A series of isolated compounds demonstrated modest to high inhibition of HNE with IC50 values of 2.3?46.1??M. In particular, luteolin-4′-O-β-D-(6″-E-caffeoyl)-glucoside (7) showed noncompetitive inhibition kinetics against HNE. The results of this study support the traditional use of polyphenol-rich products in the prevention and treatment of respiratory disease

ISSN 

1756-4646

Link 

http://dx.doi.org/10.1016/j.jff.2016.http://dx.doi.org/10.018

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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