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Title 

Metabolic adaptation in obesity and type II diabetes: myokines, adipokines and hepatokines

Authors 

Kyoung Jin OhDa Som LeeWon Kon KimBaek Soo HanSang Chul LeeKwang-Hee Bae

Publisher 

MDPI AG

Issue Date 

2017

Citation 

International Journal of Molecular Sciences, vol. 18, no. 0, pp. 8-8

Keywords 

AdipokinesHepatokinesMyokinesObesityType II diabetes

Abstract 

Obesity and type II diabetes are characterized by insulin resistance in peripheral tissues. A high caloric intake combined with a sedentary lifestyle is the leading cause of these conditions. Whole-body insulin resistance and its improvement are the result of the combined actions of each insulin-sensitive organ. Among the fundamental molecular mechanisms by which each organ is able to communicate and engage in cross-talk are cytokines or peptides which stem from secretory organs. Recently, it was reported that several cytokines or peptides are secreted from muscle (myokines), adipose tissue (adipokines) and liver (hepatokines) in response to certain nutrition and/or physical activity conditions. Cytokines exert autocrine, paracrine or endocrine effects for the maintenance of energy homeostasis. The present review is focused on the relationship and cross-talk amongst muscle, adipose tissue and the liver as secretory organs in metabolic diseases.

ISSN 

1422-0067

Link 

http://dx.doi.org/10.3390/ijms18010008

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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