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Title 

The discovery of novel protein tyrosine phosphatase ε inhibitors using a high-throughput screening approach

Authors 

Hye-Yeoung YunBonsu KuHye Seon LeeHo-Chul ShinJ B ParkC H KimSeung Jun Kim

Publisher 

The Korean Chemical Society

Issue Date 

2017

Citation 

Bulletin of the Korean Chemical Society

Keywords 

Chemical libraryHigh-throughput screeningInhibitorOsteoporosisProtein tyrosine phosphatase

Abstract 

Protein tyrosine phosphatase epsilon (PTPε) is important for signal transduction in osteoclasts, and is considered to be an attractive drug target for the treatment of osteoporosis. We identified 11 potent PTPε inhibitors based on three chemical scaffolds through the high-throughput screening of a chemical library. As these compounds are structurally diverse with high bioavailability, they warrant further investigation in the near future. The discovery of these inhibitors and the relationship between their structure and inhibitory activity toward PTPε is discussed in detail.

ISSN 

0253-2964

Link 

http://dx.doi.org/10.1002/bkcs.11044

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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