상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Authors 

H K ChungD RyuK S KimJ Y ChangY K KimH S YiS G KangM J ChoiS E LeeS B JungM J RyuS J KimG R KweonH KimJung Hwan HwangChul Ho LeeS J LeeC E WallM DownesR M EvansJ AuwerxM Shong

Publisher 

Rockefeller University Press

Issue Date 

2017

Citation 

Journal of Cell Biology

Abstract 

Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and-non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPRmt), an adaptive stress-response pathway activated by mitochondrial proteotoxic stress. Using mice with skeletal muscle-specific deficiency of Crif1 (muscle-specific knockout [MKO]), an integral protein of the large mitoribosomal subunit (39S), we identified growth differentiation factor 15 (GDF15) as a UPRmt-associated cell-non-autonomous myomitokine that regulates systemic energy homeostasis. MKO mice were protected against obesity and sensitized to insulin, an effect associated with elevated GDF15 secretion after UPRmt activation. In ob/ob mice, administration of recombinant GDF15 decreased body weight and improved insulin sensitivity, which was attributed to elevated oxidative metabolism and lipid mobilization in the liver, muscle, and adipose tissue. Thus, GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin resistance

ISSN 

0021-9525

Link 

http://dx.doi.org/10.1083/jcb.201607110

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


Files in This Item: SizeFormat
14635.pdf3338KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)