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Title 

Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III

Authors 

Jong Lyul ParkY S LeeN KunkeawSeon-Young KimI H Kim

Publisher 

Future Medicine

Issue Date 

2017

Citation 

Epigenomics

Keywords 

epigenetic regulationnc886RNA polymerase III

Abstract 

RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.

ISSN 

1750-1911

Link 

http://dx.doi.org/10.2217/epi-2016-0108

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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