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Title 

NPS2143 inhibits MUC5AC and proinflammatory mediators in cigarette smoke extract (CSE)-stimulated human airway epithelial cells

Authors 

Jae Won LeePark Ji WonOk-Kyoung KwonH J LeeH G JeongJ H KimSei-Ryang OhKyung Seop Ahn

Publisher 

Springer Verlag (Germany)

Issue Date 

2017

Citation 

Inflammation

Keywords 

chronic obstructive pulmonary diseasecigarette smokeMAPKsMUC5ACNF-κBNPS2143

Abstract 

Mucus overproduction is a fundamental hallmark of COPD that is caused by exposure to cigarette smoke. MUC5AC is one of the main mucin genes expressed in the respiratory epithelium, and its transcriptional upregulation often correlates with increased mucus secretion. Calcium-sensing receptor (CaSR) antagonists have been reported to possess anti-inflammatory effects. The purpose of the present study was to investigate the protective role of NPS2143, a selective CaSR antagonist on cigarette smoke extract (CSE)-stimulated NCI-H292 mucoepidermoid human lung cells. Treatment of NPS2143 significantly inhibited the expression of MUC5AC in CSE-stimulated H292 cells. NPS2143 reduced the expression of MMP-9 in CSE-stimulated H292 cells. NPS2143 also decreased the release of proinflammatory cytokines such as IL-6 and TNF-α in CSE-stimulated H292 cells. Furthermore, NPS2143 attenuated the activation of MAPKs (JNK, p38, and ERK) and inhibited the nuclear translocation of NF-κB in CSE-stimulated H292 cells. These results indicate that NPS2143 had a therapeutic potential in COPD

ISSN 

0360-3997

Link 

http://dx.doi.org/10.1007/s10753-016-0468-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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