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Title 

Salvia plebeia R.Br. inhibits signal transduction of IL-6 and prevents ovariectomy-induced bone loss by suppressing osteoclastogenesis

Authors 

Mi Hwa KimKyungsook JungKi Hoan NamHyun Jae JangSeung Woong LeeYesol KimChan Sun ParkT H LeeJ H ParkJ H ChoiMun Chual RhoHyun-Mee Oh

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2016

Citation 

Archives of Pharmacal Research

Keywords 

Bone mineral densityInterleukin-6OsteoclastOsteoporosisSalvia plebeia R.Br

Abstract 

The interleukin-6 (IL-6) family of cytokines plays a key role in the pathogenesis of rheumatoid arthritis and osteoporosis through the regulation of bone formation and resorption. In this study, it was observed that ethanol extract of Salvia plebeia R.Br. (S.P-EE) inhibited IL-6-induced signaling cascade including phosphorylation of JAK2/STAT3 and ERK. Subsequently, it was examined whether S.P-EE treatment could recover bone loss in ovariectomized (OVX) mice. Indeed, S.P-EE exhibited both preventive and therapeutic effect on OVX-induced bone loss in trabecular microarchitecture along with significant increase in bone mineral density and content. To understand the mechanism of action of S.P-EE in bone metabolism, the effect of S.P-EE on osteoclast differentiation and activity was investigated. S.P-EE significantly inhibited RANKL-induced osteoclast differentiation by suppressing phosphorylation of MAPK and Akt, and expression of NFATc1 and osteoclast marker genes. S.P-EE also inhibited bone-resorbing activity of osteoclasts. Furthermore, isolation and identification of the active compounds which are responsible for the inhibitory effect of S.P-EE on osteoclast differentiation was carried out. Six major flavonoids and plebeiolide A?C were isolated and examined their effects on osteoclast differentiation. Luteolin and hispidulin, and plebeiolide A and C, not B exhibited potent inhibitory activity on RANKL-induced osteoclast formation.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-016-0810-0

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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