상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Octaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum

 

항말라리아 Octaminomycins A와 B

Authors 

Jun-Pil JangT NogawaY FutamuraT ShimizuD HashizumeS YakahashiJae-Hyuk JangJong Seog AhnH Osada

Publisher 

American Chemical Society

Issue Date 

2017

Citation 

Journal of Natural Products

Abstract 

Two new cyclic octadepsipeptides, octaminomycins A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces sp. RK85-270 based on Natural Products Plot screening. Their structures were elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopic data, and MS/MS experiments for sequence analysis. The absolute configurations of the constituent amino acid residues were determined by a combination of single-crystal X-ray diffraction and Marfey's methodology. Notably, octaminomycins A (1) and B (2) showed good in vitro antiplasmodial activity against chloroquine-sensitive as well as chloroquine-resistant strains with no cytotoxicity up to 30 μM. (Chemical Equation Presented)

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/acs.jnatprod.6b00758

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)