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Title 

Biomaterials and culture technologies for regenerative therapy of liver tissue

 

간의 재생 치료를 위한 생체재료와 배양 기법

Authors 

R A PerezJung Cho RokH W Kim

Publisher 

Wiley-VCH Verlag

Issue Date 

2017

Citation 

Advanced Healthcare Materials

Keywords 

biomaterialsculture technologyliver tissueregenerative therapy

Abstract 

Regenerative approach has emerged to substitute the current extracorporeal technologies for the treatment of diseased and damaged liver tissue. This is based on the use of biomaterials that modulate the responses of hepatic cells through the unique matrix properties tuned to recapitulate regenerative functions. Cells in liver preserve their phenotype or differentiate through the interactions with extracellular matrix molecules. Therefore, the intrinsic properties of the engineered biomaterials, such as stiffness and surface topography, need to be tailored to induce appropriate cellular functions. The matrix physical stimuli can be combined with biochemical cues, such as immobilized functional groups or the delivered actions of signaling molecules. Furthermore, the external modulation of cells, through cocultures with nonparenchymal cells (e.g., endothelial cells) that can signal bioactive molecules, is another promising avenue to regenerate liver tissue. This review disseminates the recent approaches of regenerating liver tissue, with a focus on the development of biomaterials and the related culture technologies.

ISSN 

2192-2640

Link 

http://dx.doi.org/10.1002/adhm.201600791

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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