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Title 

Soy-Leaf Extract Exerts Atheroprotective Effects via Modulation of Kruppel-Like Factor 2 and Adhesion Molecules

Authors 

J M HanH LiMoon-Hee ChoSeung-Hwa BaekChul Ho LeeHo Yong ParkTae Sook Jeong

Publisher 

MDPI AG

Issue Date 

2017

Citation 

International Journal of Molecular Sciences

Keywords 

Adhesion moleculeAtherosclerosisInflammationKLF2Soy leaf

Abstract 

Soy-leaf extracts exert their cardioprotective effects by inducing endothelium-dependent vasodilation in the arteries, and they favorably modulate the serum lipid profile. In this study, we investigated the atheroprotective effects of an ethanol extract of soy leaf (ESL) in human umbilical vein endothelial cells (HUVECs) and high-cholesterol diet (HCD)-fed low-density lipoprotein receptor deficient (LDLR?/?) mice. ESL induced the expression of Kr?ppel-like factor 2 (KLF2), an endothelial transcription factor, and endothelial nitric oxide synthase (eNOS), and suppressed the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) through moderate inflammatory signal activation, not only in tumor necrosis factor-α (TNF-α)-stimulated HUVECs but also in 7-ketocholesterol (7-KC)-stimulated HUVECs. ESL supplementation reduced aortic lesion formation in Western diet-fed LDLR?/? mice by 46% (p < 0.01) compared to the HCD group. ESL also markedly decreased the aortic expression levels of VCAM-1, ICAM-1, monocyte chemotactic protein-1 (MCP-1), TNF-α, IL-6, IL-1β, matrix metallopeptidase 9 (MMP-9), and fractalkine, while the expression of KLF2 was significantly increased. These results suggest that ESL supplementation has potential for preventing HCD-induced atherosclerosis effectively

ISSN 

1422-0067

Link 

http://dx.doi.org/10.3390/ijms18020373

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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