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Title 

Tilianin inhibits MUC5AC expression mediated via down-regulation of EGFR-MEK-ERK-SP1 signaling pathway in NCI-H292 human airway cells

Authors 

W Y SongY S SongHyung Won RyuSei-Ryang OhJ T HongD Y Yoon

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2017

Citation 

Journal of Microbiology and Biotechnology

Keywords 

Chronic obstructive pulmonary diseasecigarette smokeMAPKsMUC5ACNF-κBNPS2143

Abstract 

In the human airway, mucus exists to protect the respiratory system as a primary barrier of the innate immune system. However, hyperexpressed mucus limits airflow, resulting in a decrease of lung function. Among more than 20 mucin family members, MUC5AC and MUC5B are major glycoproteins in human airway mucus. The epidermal growth factor receptor (EGFR) signaling pathway is one of the mechanisms of these mucins expression and specificity protein-1 (Sp1) transcription factor is the downstream signal of this pathway, playing pivotal roles in mucin expression. Even though there are some drugs for treating mucus hypersecretion, no drug has proven effects on humans. We found that the flavonoid tilianin regulated MUC5AC expression and also inhibited Sp1 phosphorylation. In this study, we investigated how tilianin would modulate EGFR signaling and regulate mucin production. In conclusion, tilianin inhibited MUC5AC expression mediated via modulating the EGFR-MEK-ERK-Sp1 signaling pathway in NCI-H292 human airway epithelial cells. This study may provide the basis for the novel treatment of mucus hypersecretion.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1610.10012

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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