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Title 

Protective effect of HwangRyunHaeDok-Tang water extract against chronic obstructive pulmonary disease induced by cigarette smoke and lipopolysaccharide in a mouse model

Authors 

N R ShinJ W KoS H ParkY K ChoSei-Ryang OhKyung Seop AhnJ M RyuJ C KimC S SeoI S Shin

Publisher 

Elsevier

Issue Date 

2017

Citation 

Journal of Ethnopharmacology

Keywords 

Airway inflammationChronic obstructive pulmonary diseaseCigarette smokeHwangRyunHaeDok-tangTraditional herbal formula

Abstract 

Ethnopharmacological relevance Hwangryunhaedok-tang is an oriental herbal formula treated to cure inflammation and gastric disorders in China, Japan, and Korea. We explored the protective effects of Hwangryunhaedok-tang water extract (HRWE) against airway pathophysiological changes caused by cigarette smoke (CS) and lipopolysaccharide (LPS) in a mouse. Materials and methods We performed quantitative analyses of five marker components, namely geniposide, baicalin, coptisine, plamatine, and berberine, using high-performance liquid chromatography. Animals were received CS exposure (1?h per day) for 7 days. LPS was administered intranasally on day 4. Mice were received HRWE at dose of 100 or 200?mg/kg for 1?h before CS exposure. Results Treatment with HRWE significantly suppressed the increased inflammatory cell count induced by CS and LPS exposure. In addition, reduction in IL-6, TNF-α and IL-1β in broncho-alveolar lavage fluid (BALF) was observed after HRWE treatment. HRWE not only decreased inflammatory cell infiltration in lung, but also decreased the expression of iNOS, NF-κB and matrix metallopeptidase (MMP)-9 in lung tissues. Conclusion This study showed that HRWE can attenuate respiratory inflammation caused by CS and LPS exposure. Therefore, HRWE has potential for treating airway inflammatory disease.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2017.02.027

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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