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Title 

Ginsenoside Re inhibits osteoclast differentiation in mouse bone marrow-derived macrophages and zebrafish scale model

Authors 

Chan-Mi ParkHye Min KimDong Hyun KimHo Jin HanHaneul NohJae-Hyuk JangS H ParkH J ChaeS W ChaeE K RyuSangku LeeK LiuH LiuJong Seog AhnY O KimBo Yeon KimNak Kyun Soung

Publisher 

Springer Verlag (Germany)

Issue Date 

2016

Citation 

Molecules and Cells

Keywords 

Ginsenoside ReOsteoclastsRANKLZebrafish

Abstract 

Ginsenosides, which are the active materials of ginseng, have biological functions that include anti-osteoporotic effects. Aqueous ginseng extract inhibits osteoclast differentiation induced by receptor activator of NF-κB ligand (RANKL). Aqueous ginseng extract produces chromatography peaks characteristic of ginsenosides. Among these peaks, ginsenoside Re is a major component. However, the preventive effects of ginsenoside Re against osteoclast differentiation are not known. We studied the effect of ginsenoside Re on osteoclast differentiation, RANKLinduced tartrate-resistant acid phosphatase (TRAP) activity, and formation of multinucleated osteoclasts in vitro. Ginsenoside Re hampered osteoclast differentiation in a dose-dependent manner. In an in vivo zebrafish model, aqueous ginseng extract and ginsenoside Re had antiosteoclastogenesis effects. These findings suggest that both aqueous ginseng extract and ginsenoside Re prevent bone resorption by inhibiting osteoclast differentiation. Ginsenoside Re could be important for promoting bone health

ISSN 

1016-8478

Link 

http://dx.doi.org/10.14348/molcells.2016.0111

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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