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Title 

Protective effect of polyacetylene from Dendropanax morbifera Leveille leaves on pulmonary in?ammation induced by cigarette smoke and lipopolysaccharide

 

황칠나무 polyacetylene 의 담배연기와 LPS 에 의한 폐염증 억제효과

Authors 

Jae Won LeeHyung Won RyuSu Ui LeeTae Hyun SonHyun Ah ParkMun-Ock KimHeung Joo YukKyung Seop AhnSei-Ryang Oh

Publisher 

Journal of Functional Foods

Issue Date 

2017

Citation 

Journal of Functional Foods

Keywords 

Cigarette smokeDendropanax morbifera leavesPolyacetylenePulmonary inflammation

Abstract 

As part of an ongoing search for active compounds against pulmonary inflammation, a polyacetylene was isolated from Dendropanax morbifera leaves. The polyacetylene (9Z, 16S)-16-Hydroxy-9,17-octadecadiene-12,14-diynoic acid) was isolated from the chloroform fraction of methanolic extract of D. morbifera leaves based on the IL-6 inhibitory activity evaluated in NCI-H292 cells. In the murine model of cigarette smoke (CS) and lipopolysaccharide (LPS)-induced airway inflammation, the polyacetylene significantly attenuated the infiltration of inflammatory cells in BALF (broncoalveolar lavage fluid) and in the lung. In addition, this compound reduced ROS (reactive oxygen species) production and NE (neutrophil elastase) activity, and decreased the release of proinflammatory cytokines (TNF-α, IL-6) in BALF. Furthermore, the polyacetylene reduced mucus secretion and the activation of ERK, p-38 and NF-κB in the lung. These findings suggest that the polyacetylene might be valuable constituent of D. morbifera as a material for functional food alleviating pulmonary inflammation disease such as COPD.

ISSN 

1756-4646

Link 

http://dx.doi.org/10.1016/j.jff.2017.03.007

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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