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Title 

Antiangiogenic effect of betaine on pathologic retinal neovascularization via suppression of reactive oxygen species mediated vascular endothelial growth factor signaling

 

눈의 신생혈관에서 betaine의 antiangiogenic 효과

Authors 

S W ParkH O JunE KwonJ W YunJ H KimYoung-Jun ParkB C Kang

Publisher 

Elsevier

Issue Date 

2017

Citation 

Vascular Pharmacology

Keywords 

BetaineOxygen induced retinopathyReactive oxygen speciesRetinal neovascularizationVascular endothelial growth factor

Abstract 

Reactive oxygen species (ROS) as well as vascular endothelial growth factor (VEGF) play important roles in pathologic retinal neovascularization. We investigated whether betaine inhibits pathologic retinal neovascularization in a mouse model of oxygen induced retinopathy (OIR). Betaine was intravitreally injected in OIR mice at postnatal day (P) 14. At P17, the neovascular tufts area in OIR retina was analyzed. Intravitreal injection of betaine (200?μM) effectively reduced the neovascular tufts area in OIR retina (68.0?±?6.7% of the control eyes, P?<?0.05). Even in a high concentration (2?mM), betaine never induced any retinal toxicity or cytotoxicity. Betaine significantly inhibited VEGF-induced proliferation, migration, and tube formation in human retinal microvascular endothelial cells (HRMECs). Betaine suppressed VEGF-induced VEGFR-2, Akt and ERK phosphorylation in HRMECs. In human brain astrocytes, betaine reduced tBH-induced ROS production, and subsequently attenuated tBH-induced VEGFA mRNA transcription via suppression of ROS. Our data suggest that betaine has an anti-angiogenic effect on pathologic retinal neovascularization via suppression of ROS mediated VEGF signaling. Betaine could be a potent anti-angiogenic agent to treat pathologic retinal neovascularization.

ISSN 

1537-1891

Link 

http://dx.doi.org/10.1016/j.vph.2016.07.007

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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