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Title 

Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission

Authors 

J ParkJu-Sik MinU ChaeJ Y LeeK S SongH S LeeH J LeeSang-Rae LeeD S Lee

Publisher 

Elsevier

Issue Date 

2017

Citation 

Journal of Neuroimmunology

Keywords 

Drp1InflammationMicrogliaMitochondrial dynamicsOleuropeinROS

Abstract 

Oleuropein is a primary phenolic compound found in olive leaf and Fraxinus rhynchophylla. Here, we investigated the impact of oleuropein on LPS-induced BV-2 microglial cells. Oleuropein suppressed the LPS-induced increase in pro-inflammatory mediators, such as nitric oxide, and pro-inflammatory cytokines, via inhibition of ERK/p38/NF-κB activation and reactive oxygen species (ROS) generation. Furthermore, it suppressed LPS-induced excessive mitochondrial fission, which regulates mitochondrial ROS generation and pro-inflammatory response by diminishing Drp1 dephosphorylation. Collectively, we demonstrated that oleuropein suppresses pro-inflammatory response of microglia by inhibiting Drp1-dependent mitochondrial fission. Our findings suggest a potential role of oleuropein in microglial inflammation-mediated neurodegenerative disorders.

ISSN 

0165-5728

Link 

http://dx.doi.org/10.1016/j.jneuroim.2017.02.019

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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