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Title 

Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation

Authors 

Yong Ryoul YangS SongH HwangJ H JungS J KimS YoonJ H JurJ I ParkC LeeD NamY K SeoJ H KimH RhimP G Suh

Publisher 

Nature Publishing Group

Issue Date 

2017

Citation 

Scientific Reports

Abstract 

O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga+/- mice which have an increased level of O-GlcNAcylation, and found that Oga+/- mice exhibited impaired spatial learning and memory. Consistent with this result, Oga+/- mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory

ISSN 

2045-2322

Link 

http://dx.doi.org/10.1038/srep44921

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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