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Title 

Beneficial effect of interventional exercise on autistic Fragile X syndrome

 

자폐성 취약 X증후군에서 중재운동의 효과

Authors 

S LeeJ WonS ParkSang-Rae LeeKyu Tae ChangJ H KimY Hong

Publisher 

Society of Physical Therapy Science

Issue Date 

2017

Citation 

Journal of Physical Therapy Science

Keywords 

Autism spectrum disorderFragile X syndromeTherapeutic exercise

Abstract 

[Purpose] The purpose of the present review is to discuss recent published articles in the understanding of efficacy of interventional exercise on autistic Fragile X syndrome (FXS) with special emphasis on its significance in clinical application in patients. [Methods] This review article was identified scientifically and/or clinically relevant articles from PubMed that directly/indirectly met the inclusion criteria. [Results] Mutation of fragile X mental retardation 1 (fmr1) gene on the X chromosome is related with loss of fragile X mental retardation protein (FMRP) that affecting physiological and behavioral abnormalities. Autistic FXS individuals exhibit disturbed sleep and altered circadian behavior. Although the underlying molecular mechanisms are not been fully explored, interventional exercise in autistic FXS has been clinically used for the treatment of physiological and behavioral abnormalities as well as psychiatric disorder in autistic FXS. [Conclusion] This review describes beneficial efficacy of interventional exercise and its controversy in patients with autistic FXS. This review also provides interventional strategies for clinicians and scientists that the way of neurophysiological approaches according to the level of physical and behavioral abnormalities.

ISSN 

0915-5287

Link 

http://dx.doi.org/10.1589/jpts.29.760

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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