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Title 

Superovulatory responses in cynomolgus monkeys (Macaca fascicularis) depend on the interaction between donor status and superovulation method used

Authors 

Ji-Su KimSeung-Bin YoonKang Jin JeongBo Woong SimSeon A ChoiSang Il LeeYeung Bae JinBong-Seok SongSang-Rae LeeSun-Uk KimKyu Tae Chang

Publisher 

Society for Reproduction and Development

Issue Date 

2017

Citation 

Journal of Reproduction Development

Keywords 

AgeBody weightCynomolgus monkeyMII oocyteSuperovulation

Abstract 

The current study was performed to investigate the effect of oocyte donor status, including age and body weight, on metaphase II (MII) oocyte recovery using two superovulation methods in cynomolgus monkeys. The use of Method A [recombinant gonadotrophin (75 IU/kg, 3 ×, 3-day intervals) and human chorionic gonadotropin (hCG)] led to great increases in ovary size and the mean number of MII oocytes retrieved in age- and body-weight-dependent manner; in contrast, both the parameters were similar in Method B [recombinant gonadotrophin (60 IU, twice daily, 6 days), recombinant gonadotropin and recombinant human luteinizing hormone (rhLH) (60 IU, twice daily, 3 days), and hCG]. Importantly, Method A showed maximal MII oocyte recovery rate in > 60-month-old or 4.5?5.0-kg female monkeys, whereas Method B was equally effective regardless of the donor age and body weight. These results indicate that superovulatory responses depend on the interaction between oocyte donor status and the superovulation method used in cynomolgus monkeys

ISSN 

0916-8818

Link 

http://dx.doi.org/10.1262/jrd.2016-074

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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