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Title 

Cytokine?induced killer cells hunt individual cancer cells in droves in a mouse model

Authors 

J S KimY G KimH K LeeE J ParkB KimJong Soon KangH LeeY KimJ T HongS B Han

Publisher 

Springer Verlag (Germany)

Issue Date 

2017

Citation 

Cancer Immunology, Immunotherapy

Keywords 

CytotoxicityNatural killer cellsThreshold numberTime-lapse imaging

Abstract 

Cytotoxicity of cytokine-induced killer (CIK) cells depends mainly on their encounters with target cells, but how many CIK cells are required to kill an individual cancer cell is unknown. Here we used time-lapse imaging to quantify the critical effector cell number required to kill an individual target cell. CIK cells killed MHC-I-negative and MHC-I-positive cancer cells, but natural killer (NK) cells destroyed MHC-I-negative cells only. The average threshold number of CIK cells required to kill an individual cancer cell was 6.7 for MHC-I-negative cells and 6.9 for MHC-I-positive cells. That of NK cells was 2.4 for MHC-I-negative cells. Likely due to the higher threshold numbers, killing by CIK cells was delayed in comparison with NK cells: 40% of MHC-negative target cells were killed after 5?h when co-cultured with CIK cells and after 2?h with NK cells. Our data have implications for the rational design of CIK cell-based immunotherapy of cancer patients

ISSN 

0340-7004

Link 

http://dx.doi.org/10.1007/s00262-016-1934-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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