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Title 

Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans

Authors 

Ji Young ParkSu Hwan LimBo Ram KimHyung Jae JeongHyung Jun KwonG Y SongYoung Bae RyuWoo Song Lee

Publisher 

Elsevier

Issue Date 

2017

Citation 

Bioorganic & Medicinal Chemistry Letters

Keywords 

Malabaricone CMyristica fragransNanANanBSialidase

Abstract 

Sialidases are key virulence factors that remove sialic acid from host cell surface glycans, thus unmasking receptors to facilitate bacterial adherence and colonization. In this study, we report the isolation and characterization of novel inhibitors of the Streptococcus pneumoniae sialidases NanA, NanB, and NanC from Myristica fragrans seeds. Of the isolated compounds (1?12), malabaricone C showed the most pneumococcal sialidases inhibition (IC50 of 0.3?μM for NanA, 3.6?μM for NanB, and 2.9?μM for NanC). These results suggested that malabaricone C and neolignans could be potential agents for combating S. pneumoniae infection agents

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2017.05.055

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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