상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Cytotoxic and apoptosis-inducing activities against human lung cancer cell lines of cassaine diterpenoids from the bark of Erythrophleum fordii

Authors 

M T HaM H TranT T PhuongJ A KimM H WooJ S ChoiS LeeJ H LeeHyeong Kyu LeeM S Min

Publisher 

Elsevier

Issue Date 

2017

Citation 

Bioorganic & Medicinal Chemistry Letters

Keywords 

ApoptosisCassaine diterpene alkaloidErythrophleum fordiiNon-small cell lung cancers (NSCLC)

Abstract 

A phytochemical investigation into the bark of Erythrophleum fordii yielded four new compounds, two new cassaine diterpenoids (erythrofordin T and U, 1 and 2) and two new cassaine diterpenoid amines (erythroformine A and B, 6 and 7), as well as nine known compounds. We report for the first time the isolation of erythrofordin V (3) from a natural source and that of the remaining eight known diterpenoids (4?5, 8?13) from E. fordii. All structures were elucidated using spectroscopic analysis. Cytotoxic activity of the isolated compounds (1?13) was examined in vitro against three non-small cell lung cancer cell lines (A549, NCI-H1975, and NCI-H1229) using the MTT assay. Cassaine diterpene amines (6?10, 12, 13) exhibited potent cytotoxic activity against all three cell lines with IC50 values between 0.4?μM and 5.9?μM. Erythroformine B (7) significantly induced apoptosis in all three cancer cells in a concentration-dependent manner

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2017.05.006

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)