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Title 

Gut microbiome, a potent modulator of epigenetics in human diseases

 

장내세균의 인간질환 후성유전체 조절인자로써의 가능성

Authors 

Jung Ae Kim

Publisher 

Korean journal of virology

Issue Date 

2017

Citation 

Journal of Bacteriology & Virology

Keywords 

EpigeneticsGut microbiomeMetabolism

Abstract 

Human physiology and pathology can be affected by different nutritional conditions. At cellular level, the availability of a nutritional component not only mediates metabolic reactions but also transmits signals for diverse biological activities. Epigenetic regulation such as DNA methylation and histone post-translational modifications is considered as one of the nutrient-mediated signaling receivers as almost all of the epigenetic enzyme activities require intermediary metabolites as cofactors. The gut microbiome as "forgotten organ" has been suggested as a metabolite generator as well as a nutrient sensor for its host organism, affecting human health and diseases. Given the metabolite-dependent activities of epigenetic regulators, the gut microbiome has a high potential to influence the epigenetics in human physiology. Here, I review the involvement of gut microbiome in diverse human diseases and the mechanisms of epigenetic regulation by different metabolites. Thereafter, I discuss how the gut microbiome-generated metabolites affect host epigenetics, raising a possibility to develop a therapeutic intervention based on the interaction between the microbiome and epigenetics for human health.

ISSN 

1225-2344

Link 

http://dx.doi.org/10.4167/jbv.2017.47.2.75

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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