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Title 

Esculetin exerts anti-proliferative effects against non-small-cell lung carcinoma by suppressing specificity protein 1 in vitro

Authors 

R H LeeY J JeonJ H ChoJ Y JangI K KongSeok Ho KimM S KimH J ChungK B OhS M ParkJ C ShinJ M SeoS KoJ H ShimJ I Chae

Publisher 

Rand d Print

Issue Date 

2017

Citation 

General Physiology and Biophysics

Keywords 

ApoptosisEsculetinNon-small-cell lung carcinomaSpecificity protein 1

Abstract 

Esculetin, a coumarin derivative, is a phenolic compound isolated from Artemisia capillaris, Citrus limonia, and Euphorbia lathyris. Although it has been reported to have anti-inflammatory, anti-oxidant, and anti-proliferative activities in several human cancers, its anti-proliferative activity against non-small-cell lung carcinoma (NSCLC) and the molecular mechanisms involved have not been adequately elucidated. In this study, we used two NSCLC cell lines (NCI-H358 and NCI-H1299) to investigate the anti-proliferative activity and apoptotic effect of esculetin. Our data showed that esculetin-treated cells exhibited reduced proliferation and apoptotic cell morphologies. Intriguingly, the transcription factor specificity protein 1 (Sp1) was significantly suppressed by esculetin in a dose- and time-dependent manner. Furthermore, the levels of p27 and p21, two key regulators of the cell cycle, were up-regulated by the esculetin-mediated down-regulation of Sp1; the level of a third cell-cycle regulator, survivin, was decreased, resulting in caspase-dependent apoptosis. Therefore, we conclude that esculetin could be a potent anti-proliferative agent in patients with NSCLC

ISSN 

0231-5882

Link 

http://dx.doi.org/10.4149/gpb_2016024

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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