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Title 

Platycodin D inhibits osteoclastogenesis by repressing the NFATc1 and MAPK signaling pathway

Authors 

J H ChoiY HanY A KimS W JinG H LeeH M JeongHyun Sun LeeY C ChungY C LeeE J KimK Y LeeH G Jeong

Publisher 

Wiley-Blackwell

Issue Date 

2017

Citation 

Journal of Cellular Biochemistry

Keywords 

BONE LOSSOSTEOCLASTOVARIECTOMYPLATYCODIN DPLATYCODON GRANDIFLORUMSAPONINS

Abstract 

Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) are reported to have many pharmacological activities. In our latest research, CKS was proven to have a significant osteogenic effect. However, the detail molecular mechanism of CKS on osteoclastic differentiation has not been fully investigated. Administration of CKS considerably reduced OVX-induced bone loss, and ameliorated the reduction in plasma levels of alkaline phosphatase, calcium, and phosphorus observed in OVX mice. CKS also repressed the deterioration of bone trabecular microarchitecture. Interestingly, platycodin D, the most abundant and major pharmacological constituent of triterpenoid CKS, inhibited receptor activator of NF-κB ligand (RANKL)-induced activation of NF-κB, and ERK and p38 MAPK, ultimately repressing osteoclast differentiation. OVX-induced bone turnover was attenuated by CKS, possibly via repression of osteoclast differentiation by platycodin D, the active component of CKS. Platycodin D can be regarded as an antiosteoporotic candidate for treatment of osteoporosis diseases. J. Cell. Biochem. 118: 860?868, 2017

ISSN 

0730-2312

Link 

http://dx.doi.org/10.1002/jcb.25763

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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