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Title 

Luteolin-induced apoptosis through activation of endoplasmic reticulum stress sensors in pheochromocytoma cells

Authors 

K KwonY S KwonS W KimKweon YuK H LeeO Y Kwon

Publisher 

Spandidos Publications

Issue Date 

2017

Citation 

Molecular Medicine Reports

Keywords 

ApoptosisAutophagyEndoplasmic reticulum stressLuteolinPC12 cells

Abstract 

Luteolin [2-(3,4-dihydroxyphenyl)-5,7-dilry-droxy-4-chromenone] is an active flavonoid compound from Lonicera japonica (Caprifoliaceae). Luteolin inhibits tumor cell proliferation, inflammatory and oxidative stress better, when compared with other flavonoids. In the present study, it was demonstrated that luteolin induces typical apoptosis in PC12 cells (derived from a pheochromocytoma of the rat adrenal medulla) accompanied by DNA fragmentation and formation of apoptotic bodies. In addition, luteolin regulates expression of the endoplasmic reticulum (ER) chaperone binding immunoglobulin protein, activating ER stress sensors (eukaryotic initiation factor 2a phosphorylation and X-box binding protein 1 mRNA splicing) and induced autophagy. The results indicated that luteolin induces the upregulation of the unfolded protein response pathway through the ER stress sensors, which helps as an influential regulator for the apoptosis pathway in PC12 cells. The results suggested that the understanding of the molecular mechanisms underlying lute-olin-induced apoptosis may be useful in cancer therapeutics, chemoprevention and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.

ISSN 

1791-2997

Link 

http://dx.doi.org/10.3892/mmr.2017.6582

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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