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Title 

Lectin from Sambucus sieboldiana abrogates the anoikis resistance of colon cancer cells conferred by N-acetylglucosaminyltransferase V during hematogenous metastasis

Authors 

Kyoung Jin SongSeong Kook JeonSu Bin MoonJin Suk ParkJang Seong KimJ KimS KimH J AnJeong Heon KoYong Sam Kim

Publisher 

Impact Journals

Issue Date 

2017

Citation 

Oncotarget

Keywords 

AnoikisMetastasisMGAT5SSA

Abstract 

Anoikis is a form of anchorage-dependent apoptosis, and cancer cells adopt anokis-resistance molecular machinery to conduct metastasis. Here, we report that N-acetylglucosaminyltransferase V gene expression confers anoikis resistance during cancer progression. Overexpression of N-acetylglucosaminyltransferase V protected detached cancer cells from apoptotic death, and suppression or knockout of the gene sensitized cancer cells to the apoptotic death. The gene expression also stimulated anchorage-dependent as well as anchorage-independent colony formation of cancer cells following anoikis stress treatments. Importantly, treatment with the lectin from Sambucus sieboldiana significantly sensitized anoikis-induced cancer cell deaths in vitro as well as in vivo. We propose that the lectin alone or an engineered form could offer a new therapeutic treatment option for cancer patients with advanced tumors

ISSN 

1949-2553

Link 

http://dx.doi.org/10.18632/oncotarget.15034

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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