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Title 

Chrysophanol suppressed glutamate-induced hippocampal neuronal cell death via regulation of dynamin-related protein 1-dependent mitochondrial fission

Authors 

U ChaeJu-Sik MinH H LeemH S LeeH J LeeSang-Rae LeeD S Lee

Publisher 

Karger Publishers

Issue Date 

2017

Citation 

Pharmacology

Keywords 

ChrysophanolDynamin-related protein 1Mitochondrial fissionNeuronal cell deathReactive oxygen species

Abstract 

Chrysophanic acid, or chrysophanol, is an anthraquinone found in Rheum palmatum, which was used in the preparation of oriental medicine in ancient China. The hippocampus plays a major role in controlling the activities of the short- and long-term memory. It is one of the major regions affected by excessive cell death in Alzheimer's disease. Therefore, neuronal cell-death modulation in the hippocampus is important for maintaining neuronal function. We investigated chrysophanol's effects on glutamate-induced hippocampal neuronal cell death. Chrysophanol reduced glutamate-induced cell death via suppression of proapoptotic factors and reactive oxygen species generation. Furthermore, it downregulated glutamate-induced mitochondrial fission by inhibiting dynamin-related protein 1 (Drp1) dephosphorylation. Thus, chrysophanol suppressed hippocampal neuronal cell death via inhibition of Drp1-dependent mitochondrial fission, and can be used as a therapeutic agent for treating neuronal cell death-mediated neurodegenerative diseases.

ISSN 

0031-7012

Link 

http://dx.doi.org/10.1159/000477814

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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